Age-related changes in bone architecture
نویسندگان
چکیده
منابع مشابه
Age-related changes in mouse bone permeability.
The determination of lacunar-canalicular permeability is essential for understanding local fluid flow in bone, which may indicate how bone senses changes in the mechanical environment to regulate mechano-adaptation. The estimates of lacunar-canalicular permeability found in the literature vary by up to eight orders of magnitude, and age-related permeability changes have not been measured in non...
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Background and Objectives: Oxidative stress (OS) associated with estrogen deficiency in menopause has been implicated in various complications of menopause. Some indices of OS, bone metabolism, and uric acid (UA) in postmenopausal women were assessed as possible predictors of gouty osteoarthritis. Materials and Methods: This case-control study enrolled 40 postmenopausal women and 60 premenopau...
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Bone strength, which is resistance to fracture, depends not only on the bone mass, but also on its spatial distribution (microand macroarchitecture) and the intrinsic properties of the materials that constitute the bone [1]. A particular feature of the bone is the ability to adapt its size and shape in response to mechanical loads, through the process of modeling achieved by the independent act...
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INTRODUCTION: There is strong evidence for genetic contributions to bone mass and architecture in mice and humans. Inbred mouse strains have recently been established as a valuable tool for studying the genetic regulation of skeletal phenotypes. We previously reported sex-related differences in age-related bone loss in C57Bl/6J mice [1] and mouse strain-related differences in the skeletal respo...
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Mutations in lamins cause premature aging syndromes in humans, including the Hutchinson-Gilford Progeria Syndrome (HGPS) and Atypical Werner Syndrome. It has been shown that HGPS cells in culture undergo age-dependent progressive changes in nuclear architecture. However, it is unknown whether similar changes in nuclear architecture occur during the normal aging process. We have observed that ma...
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ژورنال
عنوان ژورنال: Revista do Colégio Brasileiro de Cirurgiões
سال: 2016
ISSN: 0100-6991
DOI: 10.1590/0100-69912016004010